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10570460 Fusion genes associated with progressive prostate cancer  
The present invention relates to methods and compositions for determining whether a subject having prostate cancer is at greater risk of developing progressive disease, and methods of treating the...
10570458 Methods for diagnosis, prognosis and treatment of primary and metastatic basal-like breast cancer and other cancer types  
In one embodiment, methods of theranostic classification of a breast cancer tumor are provided, wherein the classification is determined by detecting an expression level of FOXC1. In other...
10570455 DNA methylation biomarkers for bladder cancer  
A method for the prediction, prognosis and/or diagnosis of bladder cancer or bladder cancer recurrence in a subject, the method includes: providing a test sample from the subject; measuring DNA...
10570454 Methods of identifying individuals at increased risk of lung cancer  
The invention provides the identification of oncogenic pathways activated in cytologically normal airway cells of individuals having or at risk of having lung disease, as well as specific gene...
10570398 Methods and compositions involving transmembrane and coiled-coil domains 3 (TM-CO3) in cancer  
Certain embodiments provide methods and compositions related to clinical management of cancer patients based on the expression level of TMCO3. Further embodiments involve methods and compositions...
10570371 Methods for isolating and proliferating autologous cancer antigen-specific CD8+T cells  
Provided is a method for isolating and proliferating autologous cancer antigen-specific CD8+ T cells, and more particularly, a method for selecting an epitope recognized by CD8+ T cells from...
10570214 Anti-epidermal growth factor receptor variant III chimeric antigen receptors and use of same for the treatment of cancer  
The invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular...
10570202 Combination of a PD-1 antagonist and a VEGFR inhibitor for treating cancer  
The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a VEGFR inhibitor, and the use of the combination therapies for the...
10570168 2′ and/or 5′ amino-acid ester phosphoramidate 3′-deoxy adenosine derivatives as anti- cancer compounds  
Disclosed are chemical compounds, the compounds for use in a method of treatment, particularly in a method of prophylaxis or treatment for cancer, a process for preparation of the compounds and...
10568968 Methods for treatment of cancer with therapeutic combinations comprising PEG-IL-10  
Provided are methods of treatment for tumors. In particular, methods are provided for use of a chemically modified IL-10 to treat tumors.
10568962 Hyperthermia targeting compositions, devices, and methods for cancer therapy  
A method of cancer hyperthermia therapy includes placing a device including an exogenously-excitable polymeric material at a cancer hyperthermia therapy site of a patient. The method also includes...
10568948 Vaccines for treatment and prevention of cancer  
Provided are compositions useful as therapeutic vaccines (e.g., cancer vaccines), and methods of producing such compositions. The compositions disclosed herein generally employ a stress protein...
10568947 Treatment of cancer using a CLL-1 chimeric antigen receptor  
The invention provides compositions and methods for treating diseases associated with expression of CLL-1. The invention also relates to chimeric antigen receptor (CAR) specific to CLL-1, vectors...
10568929 Engineered anthrax protective antigen proteins for cancer therapy  
Engineered anthrax protective antigen (PrAg) proteins are provided wherein the native furin activation site is replaced by the activation site of a membrane-anchored serine protease. These...
10568926 Use of des-aspartate-angiotensin I to treat patients exhibiting malignant growth, invasive growth, tumor, tumor metastasis or cancer  
The present disclosure generally relates to the use of des-aspartate-angiotensin I and/or its derivatives in medicine. In particular, the present disclosure relates to the use of...
10568909 Peptides and combination of peptides for use in immunotherapy against epithelial ovarian cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10568899 Combinations of a mithramycin analogue and another chemotherapeutic agent for the treatment of triple negative breast cancer  
A composition comprising: a) a compound of Formula (I), or a salt, co-crystal or solvate thereof; andb) at least one chemotherapeutic agent, or a salt, co-crystal or solvate thereof, suitable for...
10568887 Combination therapies for treatment of cancer  
Combination therapies for treatment of cancer are provided. The disclosed methods comprise administration of a cyclin-dependent kinase inhibitor and a DNA methyltransferase inhibitor to a mammal...
10568880 Glucocorticoid receptor modulators to treat cervical cancer  
Methods for treating a subject having a cancerous tumor are disclosed. The methods comprise administering to the subject an effective amount of a non-steroidal selective glucocorticoid receptor...
10568873 Safranal-sorafenib combination therapy for liver cancer  
A therapeutic combination of drugs for the treatment of a liver cancer includes safranal or a pharmaceutically acceptable pro-drug thereof, and sorafenib. In representative embodiments, the...
10568869 Methods for diagnosing and treating prostate cancer  
The invention is directed to a method of inhibiting prostate cancer cell proliferation using a substance that inhibits the activity of a soluble adenylyl cyclase (sAC) protein. The invention also...
10568541 Breath analysis systems and methods for asthma, tuberculosis and lung cancer diagnostics and disease management  
Methods and systems are disclosed for the detecting of whether a subject has a lung disorder such as asthma, tuberculosis or lung cancer. Monitoring the subject's health and prognosis is also...
RE47860 Methods of treating cancer with low density lipoprotein-related protein 6 (LRP6)—half life extender constructs  
The present invention relates to LRP6 constructs that bind to LRP6 receptor. The LRP6 constructs comprise at least one LRP6 binding moiety and a half-life extender molecule such that the LRP6...
10565479 Identifying and excluding blurred areas of images of stained tissue to improve cancer scoring  
A method for identifying blurred areas in digital images of stained tissue involves artificially blurring a learning tile and then training a pixel classifier to correctly classify each pixel as...
10565430 Histology recognition to automatically score and quantify cancer grades and individual user digital whole histological imaging device  
Digital pathology is the concept of capturing digital images from glass microscope slides in order to record, visualize, analyze, manage, report, share and diagnose pathology specimens. The...
10563267 Polymorphism biomarkers predict clinical outcomes of cancer patients receiving regorafenib  
Methods are provided for determining whether a cancer patient is likely or not likely to experience HFSR (hand foot skin reaction) from a therapy comprising administration of an effective amount...
10563265 Use of RHOA in cancer diagnosis and inhibitor screening  
Disclosed are a novel method of detecting cancer, a method of screening inhibitors and anticancer agents that target cancer-related molecules, RHOA polypeptide having mutation and a polynucleotide...
10563204 Methods of treating cancer harboring hemizygous loss of TP53  
Provided herein are methods of treating a patient having a cancer that exhibits (i) a hemizygous loss of the TP53 gene; (ii) a hemizygous loss of the POLR2A gene; and/or (iii) a decreased level of...
10563197 Use of a combination of Dbait molecule and PARP inhibitors to treat cancer  
The present invention relates to the combination of a PARP inhibitor with a Dbait molecule for treating cancer.
10562890 Cancer therapeutics  
This invention relates to compounds that bind to wild-type CBFβ and inhibit CBFβ binding to RUNX proteins. The potent compounds of the invention inhibit this protein-protein interaction at low...
10562886 Anti-cancer compounds  
This invention provides, among other things, compounds useful for treating diseases such as cancer, pharmaceutical formulations containing such compounds, as well as combinations of these...
10562856 DNA2 inhibitors for cancer treatment  
Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.
10561747 Multifunctional cancer targeting nanoparticles  
Multifunctional cancer targeting nanoparticles include a magnetic central core including gold coated iron oxide, an outer layer including trimethyl chitosan microspheres and folic acid and a...
10561726 Methods of treating cancer using compositions of antibodies and carrier proteins with antibody pretreatment  
Described herein are methods, formulations and kits for treating a patient with cancer with anti-VEGF antibodies and albumin-bound chemotherapeutic/anti-VEGF antibody nanoparticle complexes.
10561718 Peptides and combination of peptides for use in immunotherapy against pancreatic cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10561717 Cryopreservation of apoptotic cancer cells for use in immunotherapy against cancer  
Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells undergoing immunogenic cell death, and...
10561716 Prostate cancer vaccine  
Androgen receptor-based vaccines for eliciting an immune reaction in vivo against cells expressing androgen receptor are disclosed. The vaccines are useful in the treatment of prostate cancer....
10561712 Treatment of cancer and inhibition of metastasis using hemoglobin beta subunit  
The beta 2 subunit of mouse hemoglobin (HBB2) has been identified as soluble factor from mouse lungs that exhibits cytostatic/cytotoxic activity against neuroblastoma lung micrometastases. The...
10561679 Double-stranded nucleic acid molecule, DNA, vector, cancer cell growth inhibitor, cancer cell migration inhibitor, and drug  
A double-stranded nucleic acid molecule for suppressing expression of non-coding RNA, the double-stranded nucleic acid molecule including: (a) a sense strand containing a nucleotide sequence...
10561676 Method for treating cancer using dual antagonists of CXCR1 and CXCR2  
What is described is a method for treating cancer in a patient in need of such treatment through the use of a dual CXCR1/2 antagonist by administering a therapeutically effective amount of a dual...
10561663 MAO inhibitors and their conjugates as therapeutics for the treatment of brain cancer  
A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that...
10561653 5-bromo-2,6-di-(1H-pyrazol-1-yl)pyrimidin-4-amine for use in the treatment of cancer  
The present invention relates to 5-bromo-2,6-di-(1H-pyrazol-1-yl)pyrimidin-4-amine, its pharmaceutically acceptable salts and co-crystals thereof and to pharmaceutical compositions comprising said...
10561652 Benzenesulfonamide derivatives of quinoxaline, pharmaceutical compositions thereof, and their use in methods for treating cancer  
Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of using these chemical entities, e.g., for treatment of cancer are described.
10561647 Use of quinoline derivatives for treating oesophageal cancer and treatment method, pharmaceutical composition and kit thereof  
Provided in the present invention are a use of quinoline derivatives for treating oesophageal cancer and a treatment method, a pharmaceutical composition and a kit thereof. The...
10557175 Method of predicting risk of recurrence of cancer  
A method for predicting risk of recurrence of cancer in an individual with cancer, the method comprising a step of assaying a cancer sample from the individual for positive expression of at least...
10556967 Anti-ADAM28 antibody for treating cancer  
The present invention provides an antibody that specifically binds to human ADAM28, inhibits enzyme activity of human ADAM28, and has an activity to suppress metastasis of a cancer cell that...
10556965 Methods and materials for treating cancer  
This document provides methods and materials related to treating cancer. For example, methods and materials for using particles (e.g., nanoparticles) containing (a) one or more molecules having...
10556964 Bispecific antibody-mediated cancer therapy with cytokine-induced killer cell  
Provided are compositions comprising a MSBODY and a cytotoxic immune cell (e.g., Cytokine-induced killer cell) to form Armed Activated CIK cells (ACCs), wherein the MSBODY comprising a first...
10556925 Compound, process for its preparation, a pharmaceutical solution containing the compound, a method of determining the presence of cancer, a kit for cancer detection, and the use of hydrolysis of the compound for the detection of cancer  
The subject of the invention is a new compound of the following chemical formula: ABZ1-Dap(O2(Cbz))2-Dap(O1)3-Dap(O2)4-Arg5-ANB6-NH2 where: ABZ stands for 2-aminobenzoic acid; DAP stands for...
10556875 Bis-diazeniumdiolate compounds as anti-cancer agents  
A series of double-component, bis O2-aryl diazeniumdiolate derivatives are provided, of which each molecule can release up to four nitric oxide molecules. These compounds show cytotoxic activities...

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